It's unclear just when Norm Macdonald and Bob Saget met, but we know that the two comics worked together beginning in the late '90s. Saget directed the 1998 film "Dirty Work," which Macdonald co-wrote and starred in (via Rotten Tomatoes). The film sees Macdonald's character founding a "revenge-for-hire" business with his friend to make money to pay for his friend's father's heart surgery. Naturally, shenanigans ensue, and the film finds its footing as a comedy.
Years later, Comedy Central hosted a series of Bob Saget roasts, where people that knew Saget could, well, roast him. Norm Macdonald participated in the series, with his episode being titled "Norm Macdonald — How Can You Not Get That?" The clip is still available to watch on Comedy Central's website.
Finally — and most recently — Saget appeared on an episode of Macdonald's YouTube series, "Quarantined with Norm Macdonald," in which guests appeared to chat with him during the COVID-19 pandemic. "We are going to talk to a famous person today," Macdonald excitedly opened the episode with, showing not only his humble side but also his sheer admiration for Saget.
The two kept in touch for over two decades, showing that true friendships can be formed in Hollywood, and it's likely that Saget will help carry Macdonald's memory and essence forward.